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jueves, 29 de octubre de 2015

ESTRUCTURAS

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  • LATEST REVIEW

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    • Structural analysis of hierarchically organized zeolites OPEN

      Sharon Mitchell, Ana B. Pinar, Jeffrey Kenvin, Paolo Crivelli, Jörg Kärger, Javier Pérez-Ramírez
      Hierarchically organized zeolites are materials retaining the crystalline order and associated functionality of bulk zeolites while also integrating a multilevel pore network. Here, the authors review the raft of techniques applied to characterize their crystal, pore and active site structures.
      20 Oct 2015
       
      doi:
       
      10.1038/ncomms9633

  • LATEST ARTICLES

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    • A mutational signature in gastric cancer suggests therapeutic strategies OPEN

      Ludmil B. Alexandrov, Serena Nik-Zainal, Hoi Cheong Siu, Suet Yi Leung, Michael R Stratton
      Cancer genome analysis has demonstrated that some breast and ovarian tumours show reduced homologous recombination, a feature that can be therapeutically exploited. Here, Alexandrov et al. search for this mutational signature in 36 different cancer types and find that some gastric tumours also harbour this mutational spectrum.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9683

    • Opposite correlations between cation disordering and amorphization resistance in spinels versus pyrochlores OPEN

      Blas Pedro Uberuaga, Ming Tang, Chao Jiang, James A. Valdez, Roger Smith, Yongqiang Wang, Kurt E. Sickafus
      Radiation can cause the amorphization of crystalline materials, which needs to be understood if they are to be used in nuclear reactors. Here, the authors show a direct correlation between amorphization resistance and disordering energetics in spinel crystals, the opposite of that observed in pyrochlores.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9750

    • Unravelling structural ambiguities in lithium- and manganese-rich transition metal oxides OPEN

      Alpesh Khushalchand Shukla, Quentin M. Ramasse, Colin Ophus, Hugues Duncan, Fredrik Hage, Guoying Chen
      Lithium and manganese-rich transition metal oxides are a class of promising battery electrodes but their structures are a subject of a controversial debate. Here, the authors use a variety of materials characterization tools to unravel the structural ambiguities in these materials.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9711

    • General synthesis of inorganic single-walled nanotubes OPEN

      Bing Ni, Huiling Liu, Peng-peng Wang, Jie He, Xun Wang
      Single walled nanotubes are promising materials for both fundamental research and advanced applications. Here, the authors develop the synthesis of four types of inorganic single walled nanotube, and show that their formation is initiated by the self-coiling of their ultrathin building blocks.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9756

    • CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells OPEN

      Ervin E. Kara, Duncan R. McKenzie, Cameron R. Bastow, Carly E. Gregor, Kevin A. Fenix, Abiodun D. Ogunniyi, James C. Paton, Matthias Mack, Diana R. Pombal, Cyrill Seillet, Bénédicte Dubois, Adrian Liston, Kelli P. A. MacDonald, Gabrielle T. Belz, Mark J. Smyth, Geoffrey R. Hill, Iain Comerford, Shaun R. McColl
      Little is known regarding migration of Th17 cells that produce distinct cytokines implicated in protection and pathology. Kara et al. show that a switch from CCR6 to CCR2 by Th17 cells defines a signature (CCR6−CCR2+) of GM-CSF+ Th17 cells and drives pathology in a mouse model of autoimmunity.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9644

    • Magnetotactic molecular architectures from self-assembly of β-peptide foldamersOPEN

      Sunbum Kwon, Beom Jin Kim, Hyung-Kyu Lim, Kyungtae Kang, Sung Hyun Yoo, Jintaek Gong, Eunyoung Yoon, Juno Lee, Insung S. Choi, Hyungjun Kim, Hee-Seung Lee
      Controlling organic materials with magnetic fields in a dynamic fashion is a challenging task. Here, the authors show that synthetic ß-peptide foldamers can be rotated at will under a dynamic magnetic field and that this can be extended to macroscopic scale objects containing these materials.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9747

    • POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation OPEN

      Boshi Wang, Aihui Ma, Li Zhang, Wei-Lin Jin, Yu Qian, Guiqin Xu, Bijun Qiu, Zhaojuan Yang, Yun Liu, Qiang Xia, Yongzhong Liu
      The transcription factor E2F1 controls the expression of multiple genes and is frequently overactivated in cancer. Here, the authors show that E2F1 is deubiquitinated by POH1 and that this enhances the role of E2F1 in cell survival, and contributes to the pathogenesis of liver cancer.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9704

    • Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing OPEN

      Andres Garelli, Fabiana Heredia, Andreia P. Casimiro, Andre Macedo, Catarina Nunes, Marcia Garcez, Angela R. Mantas Dias, Yanel A. Volonte, Thomas Uhlmann, Esther Caparros, Takashi Koyama, Alisson M. Gontijo
      The orphan ligand Dilp8 has been shown to coordinate growth and developmental timing in Drosophila. Here, using Gal4 drivers and CRISPR/Cas9 approaches, Garelli et al. identify a role for relaxin-like receptor Lgr3 in regulating the Dilp8 developmental delay pathway.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9732

    • Stem and progenitor cell division kinetics during postnatal mouse mammary gland development OPEN

      Rajshekhar R. Giraddi, Mona Shehata, Mercedes Gallardo, Maria A. Blasco, Benjamin D. Simons, John Stingl
      The stem and progenitor populations that regulate mammary gland development are debated. Giraddi et al. use experimental and mathematical approaches to show that the three lineages of the mammary gland are maintained by their own restricted progenitors, and that cycling status links to the oestrus cycle.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9487

    • Efficient purification of ethene by an ethane-trapping metal-organic frameworkOPEN

      Pei-Qin Liao, Wei-Xiong Zhang, Jie-Peng Zhang, Xiao-Ming Chen
      The separation of high purity ethene from the mixed gaseous products of cracking poses significant obstacles. Here, the authors present a metal-organic framework which, in contrast to most absorbents, selectively binds the less polar ethane thus allowing the efficient collection of the target product.
      29 Oct 2015
       
      doi:
       
      10.1038/ncomms9697
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